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As erectile dysfunction treatments evolve, combination medications are becoming the gold standard for men who want faster onset, stronger erections, and more reliable performance. Two products currently competing in this space are Rugiet Ready and Bluechew Gold.
Rugiet has been prescribing its pioneering 3-in-1 ED medication containing apomorphine since 2019, establishing the category standard. Bluechew Gold is Bluechew's brand new product that closely mirrors Rugiet Ready's formula—with one key difference: the addition of oxytocin, a hormone that isn't clinically proven to treat erectile dysfunction and, according to research, doesn't absorb effectively via sublingual administration.
While both are sublingual ED medications that combine multiple active ingredients, they are not equivalent — and understanding the differences matters.
This review breaks down ingredients, delivery method, clinical relevance, and real-world effectiveness so you can decide which option makes the most sense.
What Is Rugiet Ready?
Rugiet Ready is the original 3-in-1 sublingual erectile dysfunction medication that combines:
Sildenafil
Tadalafil
Apomorphine
Rugiet Ready pioneered this specific three-ingredient ED combination, pairing two proven PDE5 inhibitors with a centrally acting agent to support both physical and neurological components of arousal. This innovative approach introduced a new standard in ED treatment that others would later follow.
Why This Matters
Most ED medications rely on one mechanism. Rugiet Ready was designed to address multiple pathways simultaneously:
Sildenafil & Tadalafil to boost blood flow
Apomorphine to boost arousal in the brain
Faster absorption via sublingual delivery
This approach delivers more consistent results, especially for men who don't fully respond to single-ingredient ED drugs.
What Is Bluechew Gold?
Bluechew Gold is Bluechew's newest premium ED offering, introduced after Rugiet Ready established the 3-in-1 sublingual category. It closely mirrors Rugiet Ready's core concept and includes:
Sildenafil
Tadalafil
Apomorphine
Oxytocin (a hormone with no established evidence for treating erectile dysfunction)
Like Rugiet Ready, Bluechew Gold is sublingual, allowing the medication to dissolve under the tongue for quicker absorption — a departure from Bluechew's original chewable-only formats and a clear adoption of the delivery method that Rugiet Ready pioneered.
The addition of oxytocin represents Bluechew Gold's primary differentiator from Rugiet Ready's formula, though this ingredient lacks clinical validation for ED treatment and is not included in standard medical guidelines for erectile dysfunction.
Sublingual Delivery: A Key Similarity
Both Rugiet Ready and Bluechew Gold are sublingual, meaning the medication dissolves under the tongue rather than being swallowed.
Benefits of Sublingual ED Medication
Faster onset compared to traditional oral tablets
Reduced first-pass metabolism in the liver
More predictable absorption
Works in as little as 15 minutes
Rugiet Ready introduced its 3-in-1 formula as a sublingual medication first, setting the industry standard that Bluechew Gold later adopted.
Ingredient Comparison: Rugiet Ready vs Bluechew Gold
The Problem with Adding Oxytocin
One of Bluechew Gold's differentiators is the addition of oxytocin, often referred to as the "bonding" or "love" hormone. While the concept sounds appealing, the clinical reality is less convincing.
What Oxytocin Actually Does
Plays a role in social bonding, emotional connection, and trust
Is released naturally during intimacy and orgasm
Acts primarily in the brain, not the vascular system
What the Evidence Shows
The scientific evidence for oxytocin as an ED treatment is weak:
Oxytocin does not directly improve penile blood flow
Human clinical data supporting oxytocin as an ED treatment is limited and inconsistent
Major ED guidelines and standard therapies do not include oxytocin as a treatment for erectile dysfunction
No established mechanism by which oxytocin would enhance the effects already provided by the three core ingredients
The Sublingual Absorption Problem
Even more problematic: research shows that oxytocin absorbs extremely poorly via sublingual administration. Studies in male volunteers have demonstrated that sublingual oxytocin has a bioavailability of only 0.007-0.07%—essentially negligible absorption. This means that even if oxytocin were proven effective for ED (which it isn't), the sublingual delivery method used in Bluechew Gold would be highly ineffective at getting it into the bloodstream.
The research is clear: sublingual administration results in "poor bioavailability with 10-fold variation" between individuals and "would not seem a reliable route" for delivering oxytocin therapeutically. For comparison, intranasal oxytocin (the more common route) achieves only 11% bioavailability—and sublingual performs far worse at approximately 4.5%.
Oxytocin appears to be a marketing differentiator rather than a clinically meaningful addition. There's no established evidence that it enhances the core mechanisms already addressed by sildenafil, tadalafil, and apomorphine—and even if there were, the sublingual delivery method fails to deliver therapeutic amounts.
For patients seeking evidence-based treatment, adding unproven ingredients with poor absorption raises questions about whether the focus is on clinical outcomes or product differentiation.
How Rugiet Ready's 3-in-1 Formula Works
Rugiet Ready's effectiveness comes from targeting multiple systems simultaneously:
Sildenafil increases nitric oxide signaling for stronger erections
Tadalafil extends duration and spontaneity (up to 36 hours)
Apomorphine activates dopamine pathways involved in sexual arousal
This layered approach is especially useful for:
Men who don't fully respond to single-ingredient ED medications
Situations where speed of onset matters (works in as little as 15 minutes)
Performance anxiety or inconsistent arousal
Men seeking both immediate and long-lasting effects
The result is an ED treatment that works quickly and lasts long — without experimental additions of questionable benefit.
Physician-Customized Dosing: A Real Differentiator
Unlike one-size-fits-all approaches, Rugiet Ready offers physician-customized dosing tailored to individual patient needs. This allows doctors to adjust the ratio of each ingredient based on:
Individual response patterns
Side effect profile
Specific performance goals
Medical history and contraindications
This personalized approach ensures that each patient receives the optimal balance of ingredients for their unique situation — a level of customization that mass-market products cannot provide.
Effectiveness and User Experience
Rugiet Ready
Pioneered the 3-in-1 sublingual ED formula
Focuses exclusively on clinically relevant mechanisms
No added hormones without proven ED benefit
Physician-customized dosing for optimal results
Streamlined, purpose-built formulation backed by clinical rationale
Bluechew Gold
Adopted a formula closely resembling Rugiet Ready's original formulation
Adds oxytocin, which has not been shown to enhance erectile performance
One-size-fits-all dosing approach
Appeals to users already familiar with the Bluechew brand
Safety Considerations
Both medications contain prescription ED drugs and should only be used after a medical evaluation. Potential side effects include:
Headache
Flushing
Nausea
Dizziness
Blood pressure changes
Men taking nitrates or with certain cardiovascular conditions should avoid PDE5 inhibitors unless cleared by a physician. Always consult with a healthcare provider before starting any ED medication.
Final Verdict: Rugiet Ready vs Bluechew Gold
If you're looking for a clinically focused, evidence-based 3-in-1 ED medication, Rugiet Ready stands out as the original product that pioneered this combination approach — without unnecessary additions.
As the innovator in 3-in-1 sublingual ED treatment, Rugiet Ready set the standard that others have followed. The formula was designed with a clear clinical rationale: address multiple pathways of erectile function through proven mechanisms.
While Bluechew Gold adopted a formula closely resembling Rugiet Ready's original formulation, its inclusion of oxytocin does not appear to offer a clear, evidence-based advantage for erectile function. The addition raises questions about whether the goal is clinical improvement or simply product differentiation.
For men prioritizing proven mechanisms, fast onset, physician-customized treatment, and thoughtful formulation integrity, Rugiet Ready remains the benchmark in this category.
Choose the original. Choose the formula built on clinical evidence, not marketing additions.
Rugiet Ready is available by prescription only. Consult with a licensed healthcare provider to determine if it's right for you.
