Rex MD Review: What to Know Before Buying

Rex MD is a men's telehealth platform offering prescription medications for erectile dysfunction (ED), premature ejaculation (PE), testosterone, hair loss, weight management, and anxiety. Its ED lineup includes both brand-name and generic versions of Viagra and Cialis, as well as branded Levitra (vardenafil), making it one of the few telehealth platforms to provide all three of the most widely prescribed PDE5 inhibitors.

Sildenafil, tadalafil, and vardenafil are all FDA-approved medications for erectile dysfunction. Rex MD prescribes these as standard manufactured tablets, not compounded formulations.

This article reviews Rex MD's ED products, how they work, their cost, and their pros and cons.

This article is for informational purposes only and should not be taken as medical advice. If you have questions or concerns about your condition or treatment, please consult a healthcare provider.

What Is Rex MD?

What it is: Rex MD is a California-based telehealth company founded in 2019. The platform connects men with US-licensed healthcare providers through an online consultation. Prescriptions are filled by licensed pharmacies and shipped directly to the patient. Rex MD is available in all 50 states and Washington, D.C.

What it offers for ED: Rex MD offers sildenafil (generic for Viagra®) (sildenafil (generic for Viagra®)), branded Viagra, tadalafil (generic for Cialis®) (generic Cialis), branded Cialis, daily tadalafil (generic for Cialis®), and branded vardenafil (Levitra). All products are standard manufactured tablets. Rex MD does not offer compounded, chewable, or sublingual formulations for ED.

What it offers beyond ED: Rex MD treats testosterone deficiency, hair loss (finasteride), premature ejaculation (sertraline), weight loss (semaglutide), anxiety (beta blockers), and herpes (valacyclovir).

How much it costs: Generic ED medications start as low as $2/dose. Branded options start higher. See the pricing section below for details.

Pros: All three major PDE5 inhibitors available; FDA-approved medications only; broad men's health scope; competitive generic pricing.

Cons: No chewable or sublingual ED formats; no compounded combination products; standard pill format only.

Good for: Men who want access to all three major PDE5 inhibitors in standard pill form, or those who need multiple men's health treatments through one platform.

Not ideal for: Men who want chewable or sublingual formulations or compounded combination products.

Rex MD's ED Products

Sildenafil (Generic for Viagra®)

Active ingredient: Sildenafil citrate

Available dosages: 20 mg, 50 mg, and 100 mg

How it works: A PDE5 inhibitor that enhances blood flow to the penis during sexual arousal by blocking the enzyme that breaks down cGMP. Does not cause erections without sexual stimulation.

How to take it: As needed, approximately 30 to 60 minutes before sexual activity. Do not take more than once in 24 hours.

How fast it works and how long it lasts: Typically 30 to 60 minutes onset; effects last approximately 4 to 6 hours

Starting price: As low as $2/dose (20 mg); as low as $6/dose (50 mg and 100 mg)

Branded Viagra

Available dosages: 50 mg and 100 mg

Starting price: As low as $96/dose

Tadalafil (Generic for Cialis®, As-Needed)

Active ingredient: Tadalafil

Available dosages: 10 mg and 20 mg

How it works: A PDE5 inhibitor with a longer half-life than sildenafil. A single dose can support erections for up to 36 hours.

How to take it: As needed, approximately 30 to 60 minutes before sexual activity

How fast it works and how long it lasts: 30 to 60 minutes onset; up to 36 hours duration

Starting price: As low as $6/dose

Daily Tadalafil (Generic for Cialis®, Daily)

Available dosages: 2.5 mg and 5 mg

How it works: Daily low-dose tadalafil maintains a steady concentration in the bloodstream, allowing for spontaneous sexual activity without needing to time a dose before sex.

How to take it: Once daily at the same time each day, with or without food

Starting price: As low as $2/dose

Branded Cialis

Available dosages: 10 mg and 20 mg

Starting price: As low as $29/dose

Branded Vardenafil (Levitra)

Rex MD is one of the few telehealth platforms offering branded vardenafil (Levitra), the third major FDA-approved PDE5 inhibitor for ED.

How it works: Vardenafil is a PDE5 inhibitor with a similar mechanism to sildenafil and tadalafil. Some men who do not respond well to sildenafil find vardenafil more effective. Individual response to different PDE5 inhibitors can vary.

How to take it: As needed, approximately 30 to 60 minutes before sexual activity

How fast it works and how long it lasts: Approximately 30 to 60 minutes onset; effects last approximately 4 to 6 hours

Pricing: Requires completing a consultation. Rex MD offers branded Levitra rather than generic vardenafil.

Premature Ejaculation: Sertraline

For men with PE, Rex MD can prescribe sertraline (generic Zoloft), an SSRI used off-label to delay ejaculation. Sertraline increases serotonin activity, which slows the ejaculatory reflex. Starting at $27/month.

How Do Rex MD's ED Medications Work?

Sildenafil, tadalafil, and vardenafil are all PDE5 inhibitors. When sexually aroused, the brain triggers nitric oxide release in penile blood vessels, which stimulates cGMP production. cGMP relaxes smooth muscle and allows blood to fill the corpora cavernosa, producing an erection. PDE5 normally breaks cGMP down. In men with ED, this process can be disrupted. PDE5 inhibitors block that enzyme, prolonging the window for a firm erection during stimulation. All three medications work through this same mechanism but differ in onset speed, duration, and potency profile.

Side Effects of Rex MD Medications

Common side effects (PDE5 inhibitors):

• Headache
• Flushing
• Nasal congestion
• Dizziness
• Upset stomach
• Muscle or back pain
• Temporary vision changes (particularly with sildenafil)

Rare but serious:

• Sudden hearing or vision loss
• Very low blood pressure
• Priapism (an erection lasting more than 4 hours) is a medical emergency

PDE5 inhibitors should not be combined with nitrate medications, other ED drugs, or certain antihypertensives.

How to Get a Prescription Through Rex MD

The process is fully online. You complete a free health questionnaire that a Rex MD-affiliated provider reviews within approximately 24 hours. A recent blood pressure reading may be required. In some cases the questionnaire alone is sufficient; in others, a virtual appointment may be scheduled. Prescriptions ship in discreet, unmarked packaging.

How Much Does Rex MD Cost?

• Sildenafil (Generic for Viagra®): As low as $2/dose
• Tadalafil (Generic for Cialis®, as-needed): As low as $6/dose
• Daily Tadalafil (Generic for Cialis®): As low as $2/dose
• Branded Viagra: As low as $96/dose
• Branded Cialis: As low as $29/dose
• Branded Levitra (vardenafil): Consultation required
• Sertraline (PE): Starting at $27/mo Subscriptions are available in 30-day, 90-day, 180-day, and annual increments. Longer plans offer lower per-dose costs. Rex MD does not accept insurance. Shipping is free with the first order.

Rex MD Reviews and Company Reputation

Rex MD holds near 5-star ratings on Trustpilot and Review.io across several thousand reviews. Positive reviews frequently cite affordable pricing, fast shipping, discreet packaging, and ease of the online process.

Who Is Rex MD For?

Rex MD may be a reasonable option for men who:

• Want access to all three FDA-approved PDE5 inhibitors in standard pill form
• Are looking for a platform that also covers PE, testosterone, hair loss, or weight management
• Prefer branded medications, including Levitra

Who May Not Want to Choose Rex MD?

• Men who want chewable or sublingual formulations
• Men interested in compounded combination products

Is Rex MD FDA-Approved?

Yes. Rex MD's ED medications, including sildenafil (generic for Viagra®), tadalafil (generic for Cialis®), branded Viagra, branded Cialis, and branded Levitra, are all FDA-approved. Rex MD does not offer compounded formulations.

Rex MD Pros and Cons

Pros

• All three major PDE5 inhibitors available: Sildenafil, tadalafil, and vardenafil (Levitra)
• FDA-approved medications only: Standard manufactured tablets with no compounded formulations
• Broad men's health scope: ED, PE, testosterone, hair loss, and weight management on one platform
• Competitive generic pricing: Generic sildenafil as low as $2/dose; daily tadalafil as low as $2/dose

Cons

• No chewable or sublingual options
• No compounded combination products
• Branded Levitra only: Generic vardenafil is not available through Rex MD

Alternatives to Rex MD for ED

For men interested in a faster-onset combination treatment, Rugiet Ready is a sublingual lozenge combining sildenafil, tadalafil, and apomorphine in four dose tiers. Unlike standard tablets, it is designed for sublingual absorption with onset in approximately 15 minutes on average. Visit rugiet.com to learn more.

Bottom Line

Rex MD offers access to all three major FDA-approved PDE5 inhibitors in standard tablet form, alongside a broad range of other men's health treatments. A few things worth knowing before you start:

• Standard pills only. If you want chewable or sublingual formats, Rex MD is not the right fit.
• Generic pricing is competitive, with sildenafil (generic for Viagra®) and daily tadalafil available as low as $2/dose.

If you are interested in a sublingual combination with faster onset and arousal-pathway support, Rugiet Ready may be worth considering. Start your free online visit at rugiet.com.