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Erectile dysfunction (ED) can be a difficult condition to manage, but the good news is that most cases of ED are treatable. From medications to surgical intervention, there are a range of ways to improve the sexual experience for men with ED and their partners.
The first line of treatment for ED is usually oral phosphodiesterase type 5 (PDE5) inhibitors such as Viagra (sildenafil), Cialis (tadalafil), and Levitra (vardenafil). These medications have helped millions of men regain confidence in their sexual performance by improving blood flow to the penis, facilitating stronger and longer-lasting erections. (Leslie, 2024)
But what happens when the standard ED medications stop working? Whether you aren’t getting satisfactory results due to developing a tolerance, underlying health conditions, or other factors, you may find yourself looking for alternative ED treatments that can get the job done.
This is where Rugiet steps in—offering a unique combination ED treatment designed to enhance efficacy and convenience. Before diving into how Rugiet Ready can be an ideal next step, let’s explore why traditional oral ED medications sometimes stop working and what alternative treatments are available.
PDE5 inhibitors like Viagra, Cialis, and Levitra don’t offer a long-term solution for everyone. Here are some common reasons why these medications may become less effective over time:
Tolerance Build-Up
Some research suggests that it’s possible to develop a tolerance to sildenafil, the main active ingredient found in Viagra. (McMahon, 2015) Tolerance occurs when the body becomes accustomed to a certain drug or medication, requiring higher doses of the drug to achieve satisfactory effects. This could occur as a result of taking the drug itself for a long period of time, or may be tied to underlying health conditions. (Rao, 2015)
Underlying Health Conditions
Underlying conditions such as diabetes, cardiovascular disease, obesity, and high blood pressure can all worsen ED and may impact the effectiveness of PDE5 inhibitors. (Nehra, 2009) ED is often a symptom of poor vascular health, and if blood flow is severely impaired, these medications may not be strong enough to make a significant difference. If a condition is worsening, there may also be a need for higher medication dosage, meaning a lower or standard dose may not achieve the same results. (Rao, 2015)
Additionally, low levels of testosterone or other hormone imbalances can contribute to ED and may require hormone replacement therapy before satisfactory results can be achieved with ED meds. (Leslie, 2024)
Mental and Psychological Health
What some people don’t realize is that PDE5 medications do not target psychogenic ED, which can be caused by general or sexual performance anxiety, depression, stress, relationship problems, and other mental or psychological factors. (Leslie, 2024) Therapy, counseling, and other medications to treat mental health conditions or target mental arousal may be more beneficial.
Additional Factors
There are many other factors that can contribute to the efficacy of ED medications, including improper dosage, medication interactions, and more. (Leslie, 2024)If you find that the standard ED pills aren’t effective for you anymore, don’t lose hope. There are other options that may provide better results.
There are a host of other treatment options, including penile injections, implants, and more-- but before turning to a more invasive, uncomfortable, or expensive treatment, you may want to consider an alternative oral medication that offers enhanced effectiveness, faster onset, and longer-lasting results.
What Is Rugiet Ready?
Rugiet Ready is a next-generation ED treatment that combines multiple active ingredients into a single, fast-acting, sublingual tablet. By combining sildenafil (Viagra’s active ingredient), tadalafil (Cialis’s active ingredient), and apomorphine, a dopamine receptor agonist, Rugiet Ready offers a unique approach to treating ED that goes beyond the limitations of traditional single-agent pills.
Rugiet Ready isn't just another ED pill—it’s an advanced formula designed to target multiple pathways involved in erectile function.
1. Combination of Multiple Active Ingredients
Unlike traditional pills that rely on just one drug, Rugiet Ready blends three clinically proven compounds (Gong, 2017) (Hagemann, 2003):
Sildenafil – A fast-acting PDE5 inhibitor that increases blood flow to the penis.
Tadalafil – A longer-lasting PDE5 inhibitor that stays active for up to 36 hours.
Apomorphine – A dopamine agonist that stimulates sexual arousal and enhances response.
By combining these ingredients, Rugiet Ready targets both the physical and mental factors of arousal, leading to promising results for more men— even those who have not responded well to single-agent therapies.
2. Faster Absorption with Sublingual Delivery
Rugiet Ready comes in the form of an under-the-tongue tablet that dissolves within a few minutes. This mode of administration allows for rapid absorption directly into the bloodstream, bypassing the digestive system and causing effects in as little as 15 minutes, rather than the typical 30–60 minutes experienced with standard ED pills.(Hua, 2019)
3. Longer-Lasting Effects
Because Rugiet includes tadalafil, users experience a longer window of opportunity than most single-drug ED medications. Sildenafil often shows effects more quickly but fades within 4–6 hours, while tadalafil remains active for up to 36 hours, allowing for more spontaneity. (Gong, 2017)
4. Stronger and More Reliable Erections
The unique blend of PDE5 inhibitors and a dopamine agonist improves not just blood flow, but also sexual desire and arousal, leading to a more holistic solution for ED. (Hagemann, 2003)
5. Convenience and Discretion
Rugiet Ready is a discreet sublingual medication that can be taken anywhere, anytime, without hassle. This eliminates the need for careful planning around your schedule, and carrying around a bottle of pills that need to be swallowed with water. Just pop a tablet under your tongue, and you’ll be prepared for better sexual experiences within 15 minutes and up to 36 hours.
6. Approved by Men’s Health Experts
Dr. Vipul D. Khanpara, MD, Chief Medical Officer at Rugiet Health, explains that combining sildenafil, tadalafil, and apomorphine in a sublingual format provides a synergistic effect that benefits men who have struggled with traditional ED medications. This formula enhances erectile response, increases sexual arousal, and improves overall sexual performance.
Before starting any ED treatment, it's essential to consult a licensed healthcare provider. Rugiet offers an online consultation process, making it easy to determine if the medication is a good fit for you.
You should consider Rugiet if you have noticed reduced effectiveness with standard ED medications such as Viagra, Cialis, or Levitra, if you want faster results and longer-lasting effects, or if you’re looking for a more discrete and convenient ED treatment.
Rugiet physicians can customize doses of each medication specifically to each patient’s need. While we can’t promise Rugiet will work for everyone, our providers will work with you to try to deliver optimal results while minimizing side effects.
Complete an online consultation and have the medication delivered discreetly to your doorstep!
Citations:
Leslie SW, Sooriyamoorthy T. Erectile Dysfunction. [Updated 2024 Jan 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562253/
Chris G. McMahon, Culley C. Carson, Christopher J. Fischer, Wei Christine Wang, Vincent A. Florio, John D. Bradley, Tolerance to the Therapeutic Effect of Tadalafil Does Not Occur During 6 Months of Treatment: A Randomized, Double‐Blind, Placebo‐Controlled Study in Men with Erectile Dysfunction, The Journal of Sexual Medicine, Volume 3, Issue 3, May 2006, Pages 504–511, https://doi.org/10.1111/j.1743-6109.2006.00248.x
Sathyanarayana Rao, T. S., Kumar, V. A., Raman, R., & Andrade, C. (2015). Prolonged, longstanding, ultra-high-dose abuse of sildenafil. Indian journal of psychiatry, 57(3), 311–312. https://doi.org/10.4103/0019-5545.166626
Nehra A. (2009). Erectile dysfunction and cardiovascular disease: efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions. Mayo Clinic proceedings, 84(2), 139–148. https://doi.org/10.4065/84.2.139
Gong, B., Ma, M., Xie, W., Yang, X., Huang, Y., Sun, T., Luo, Y., & Huang, J. (2017). Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis. International urology and nephrology, 49(10), 1731–1740. https://doi.org/10.1007/s11255-017-1644-5
Hagemann, J. H., Berding, G., Bergh, S., Sleep, D. J., Knapp, W. H., Jonas, U., & Stief, C. G. (2003). Effects of visual sexual stimuli and apomorphine SL on cerebral activity in men with erectile dysfunction. European urology, 43(4), 412–420. https://doi.org/10.1016/s0302-2838(03)00002-2
Hua S. (2019). Advances in Nanoparticulate Drug Delivery Approaches for Sublingual and Buccal Administration. Frontiers in pharmacology, 10, 1328. https://doi.org/10.3389/fphar.2019.01328
