What is gonadorelin?

Gonadorelin is a hormone that causes the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It is a synthetic version of the naturally occurring GnRH produced in the brain.

What does this medication look like:

• It is a round, white, scored tablet.

How do I take this medication?

Gonadorelin is not taken as a tablet that is chewed or swallowed. It will be administered as a Sublingual (under the tongue) form. Place the compounded tablet under your tongue or between your cheek and gums until it fully dissolves, then swallow. To ensure proper absorption, do not eat or drink for 15 minutes before or after taking it.

What if I miss a dose?

• If you miss a dose, take it as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule.
• Do not take a double dose to make up for a missed one.

Who Should NOT Take gonadorelin?

Do not take gonadorelin if you have any of the following conditions:

• A known allergy or sensitivity to gonadorelin or its components.
• A pre-existing condition that can be worsened by reproductive hormones, such as certain tumors.
• Active ovarian cysts or certain reproductive cancers.
• Primary ovarian failure (your ovaries no longer make eggs).
• Pituitary tumors, as it could cause serious complications.
• You are pregnant or breastfeeding, unless your doctor has specifically determined that the benefits outweigh the risks.

What are the side effects?

Common side effects include:

• Headache, light-headedness, or dizziness
• Nausea, abdominal discomfort, or upset stomach
• Flushing (a warm, red feeling)
• Injection site irritation (pain, swelling, redness, or itching)
• Skin rash

More serious, but less common, side effects requiring immediate medical attention include:

• Signs of a severe allergic reaction (rash, hives, difficulty breathing, or swelling of the face, lips, or tongue).
• Ovarian Hyperstimulation Syndrome (OHSS): Severe stomach pain or bloating, significant weight gain, shortness of breath, severe nausea or vomiting, and decreased urination.
• Mental or mood changes, including depression.
• Sudden blindness (extremely rare, but has been reported in patients with a pituitary tumor).

What should I tell my doctor?

Before taking gonadorelin, inform your doctor about all of your medical conditions and other medications you take, including:

• Other medical conditions: Any allergies, ovarian cysts, tumors (including pituitary), reproductive cancers, or mental health issues.
• Other medications: List all prescription, over-the-counter, and herbal products you use. Some medications, including certain hormones and mood-altering drugs, can interfere with gonadorelin.
• Pregnancy and breastfeeding: Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Lab tests: Your doctor will need to monitor your hormone levels and may perform ultrasounds to check your progress. Keep all lab and medical appointments.

Important precautions

• High-risk pregnancy: Gonadorelin can increase the risk of getting pregnant with more than one baby. Discuss the potential risks with your doctor.
• Physical activity: Limit strenuous physical activity during ovarian stimulation. Ask your doctor for specific guidance.
• Storage: If you are storing the medication at home, follow your pharmacist's and doctor's instructions for safe storage and disposal.

Additional Information:

• Do not share this medication with others to whom it was not prescribed.
• Keep out of reach of children and pets.
• If an overdose is suspected contact your local poison control center at 1-800-222-1222 or go to the nearest emergency room.
• Do not flush down a toilet or pour down a drain. Check with your pharmacist if you have questions about the best way to dispose of medications. There may be a drug take-back program in your area.

If you have any questions concerning this or any of your medications, a pharmacist is available during normal business hours to answer your questions. You can report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.